Vector for the release of an active agent which is photocleavable by irradiation in the visible

Photocleavable molecules are of great interest as tools for diagnosis and various therapies thanks to the high spatiotemporal control over the release, but some issues preclude their clinical use. One open question is the frequency of the radiation required for the photocleaving process, which normally falls within the UV-violet region of the electromagnetic spectrum. These radiations are toxic to living cells and disadvantageous because of their short penetration depth into tissues. On the contrary, visible light and even the near infrared (NIR) result in reduced absorption and scattering, improving their penetration in tissues and reducing the toxicity. This invention relates to a new vector able to photo-release an active agent (such as a drug or a label) by visible or near infrared (NIR) triggering at low laser power.


Inventors: 
Valerio Voliani, Stefano Luin, Fernanda Ricci, Riccardo Nifosì, Giovanni Signore, Fabio Beltram
Assignees: 
Scuola Normale Superiore (27%), Istituto Italiano di Tecnologia, Consiglio Nazionale delle Ricerche
Date of filing: 
27.06.2011
Status: 
disponibile alla licenza
Type: 
Brevetti
Subject: 
Scuola Normale Superiore
Technological area: 
Materiali e nanotecnologie
Number of priority: 
WO2013001451 (A1)